Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Emma Adriana Ozon; Iulian Sarbu; Violeta Popovici; Mirela Adriana Mitu; Adina Magdalena Musuc; Oana Karampelas; Bruno Stefan Velescu

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2024.0082

Published Article

LAPSE:2024.0082

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Emma Adriana Ozon, Iulian Sarbu, Violeta Popovici, Mirela Adriana Mitu, Adina Magdalena Musuc, Oana Karampelas, Bruno Stefan Velescu

January 12, 2024

The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

Record ID

LAPSE:2024.0082

Keywords

3D inkjet printing, active pharmaceutical ingredients, buccal drug delivery, extrusion-based 3D printing methods, liquid crystal display 3D printing, oral films, personalized medicine, Polymers

Subject

Biosystems

Suggested Citation

Ozon EA, Sarbu I, Popovici V, Mitu MA, Musuc AM, Karampelas O, Velescu BS. Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview. (2024). LAPSE:2024.0082

Author Affiliations

Ozon EA: Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Sarbu I: Faculty of Pharmacy, Department of Pharmaceutical Physics and Biophysics, Drug Industry and Pharmaceutical Biotechnologies, “Titu Maiorescu” University, 004051 Bucharest, Romania [ORCID]
Popovici V: Faculty of Dental Medicine, Department of Microbiology and Immunology, “Ovidius” University of Constanta, 900684 Constanta, Romania [ORCID]
Mitu MA: Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania [ORCID]
Musuc AM: Romanian Academy, “Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl.Independentei, 060021 Bucharest, Romania [ORCID]
Karampelas O: Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Velescu BS: Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania

Journal Name

Processes

Volume

11

Issue

9

First Page

2628

Year

2023

Publication Date

2023-09-03