Silver nanoparticles, also known as AgNPs, have been extensively researched due to their one-of-a-kind characteristics, including their optical, antibacterial, and electrical capabilities. In the era of the antibiotics crisis, with an increase in antimicrobial resistance (AMR) and a decrease in newly developed drugs, AgNPs are potential candidates because of their substantial antimicrobial activity, limited resistance development, and extensive synergistic effect when combined with other drugs. The effect of AgNPs depends on the delivery system, compound combination, and their own properties, such as shape and size, which are heavily influenced by the synthesis process. Reduction using chemicals or light, irradiation using gamma ray, laser, electron beams or microwave and biological synthesis or a combination of these techniques are notable examples of AgNP synthesis methods. In this work, updated AgNP synthesis methods together with their strength and shortcomings are reviewed. Further, factors affecting the synthesis process are discussed. Finally, recent advances and challenges are considered.