This study applied regionalization techniques on future climate change scenarios for the precipitation over the Xingu River Basin (XRB) considering the 2021−2080 horizon, in order to assess impacts on the monthly flow rates and possible consequences for electricity generation at the Belo Monte Hydroelectric Power Plant (BMHPP). This is the fourth largest hydroelectric power plant in the world, with a generating capacity of 11,233 MW, and is located in the Brazilian Amazon. Two representative concentration pathways (RCP 4.5 and RCP 8.5) and an ensemble comprising four general circulation models (CanESM2, CNRM-CM5, MPI-ESM-LR and NORESM1-M) were used. The projections based on both scenarios indicated a considerable decrease in precipitation during the rainy season and a slight increase during the dry season relative to the reference period (1981−2010). According to the results, a reduction in the flow rates in Altamira and in the overall potential for power generation in the BMHPP are also to be expected in both analyzed periods (2021−2050 and 2051−2180). The RCP 4.5 scenario resulted in milder decreases in those variables than the RCP 8.5. Conforming to our findings, a reduction of 21.3% in the annual power generation at the BMHPP is expected until 2080, with a corresponding use of 38.8% of the maximum potential of the facility. These results highlight the need for investments in other renewable energy sources (e.g., wind and solar) in order to compensate for the upcoming losses in the BMHPP production.