LAPSE:2023.4320
Published Article
LAPSE:2023.4320
Innovative Gold/Cobalt Ferrite Nanocomposite: Physicochemical and Cytotoxicity Properties
February 22, 2023
Abstract
The combination of plasmonic material and magnetic metal oxide nanoparticles is widely used in multifunctional nanosystems. Here we propose a method for the fabrication of a gold/cobalt ferrite nanocomposite for biomedical applications. The composite includes gold cores of ~10 nm in diameter coated with arginine, which are surrounded by small cobalt ferrite nanoparticles with diameters of ~5 nm covered with dihydrocaffeic acid. The structure and elemental composition, morphology and dimensions, magnetic and optical properties, and biocompatibility of new nanocomposite were studied. The magnetic properties of the composite are mostly determined by the superparamagnetic state of cobalt ferrite nanoparticles, and optical properties are influenced by the localized plasmon resonance in gold nanoparticles. The cytotoxicity of gold/cobalt ferrite nanocomposite was tested using T-lymphoblastic leukemia and peripheral blood mononuclear cells. Studied composite has selective citotoxic effect on cancerous cells while it has no cytotoxic effect on healtly cells. The results suggest that this material can be explored in the future for combined photothermal treatment and magnetic theranostic.
The combination of plasmonic material and magnetic metal oxide nanoparticles is widely used in multifunctional nanosystems. Here we propose a method for the fabrication of a gold/cobalt ferrite nanocomposite for biomedical applications. The composite includes gold cores of ~10 nm in diameter coated with arginine, which are surrounded by small cobalt ferrite nanoparticles with diameters of ~5 nm covered with dihydrocaffeic acid. The structure and elemental composition, morphology and dimensions, magnetic and optical properties, and biocompatibility of new nanocomposite were studied. The magnetic properties of the composite are mostly determined by the superparamagnetic state of cobalt ferrite nanoparticles, and optical properties are influenced by the localized plasmon resonance in gold nanoparticles. The cytotoxicity of gold/cobalt ferrite nanocomposite was tested using T-lymphoblastic leukemia and peripheral blood mononuclear cells. Studied composite has selective citotoxic effect on cancerous cells while it has no cytotoxic effect on healtly cells. The results suggest that this material can be explored in the future for combined photothermal treatment and magnetic theranostic.
Record ID
Keywords
localized plasmonic resonance, magneto-plasmonic nanoparticles, photothermal therapy
Subject
Suggested Citation
Motorzhina A, Jovanović S, Belyaev VK, Murzin D, Pshenichnikov S, Kolesnikova VG, Omelyanchik AS, Gazvoda L, Spreitzer M, Panina L, Rodionova V, Vukomanović M, Levada K. Innovative Gold/Cobalt Ferrite Nanocomposite: Physicochemical and Cytotoxicity Properties. (2023). LAPSE:2023.4320
Author Affiliations
Motorzhina A: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
Jovanović S: Laboratory of Physics, Vinca Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11001 Belgrade, Serbia; Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia [ORCID]
Belyaev VK: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia [ORCID]
Murzin D: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Pshenichnikov S: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
Kolesnikova VG: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Omelyanchik AS: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia [ORCID]
Gazvoda L: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
Spreitzer M: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
Panina L: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; College of New Materials and Nanotechnologies, National University of Science and Technology MISiS, 119991 Moscow, Russia
Rodionova V: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Vukomanović M: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia [ORCID]
Levada K: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
Jovanović S: Laboratory of Physics, Vinca Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11001 Belgrade, Serbia; Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia [ORCID]
Belyaev VK: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia [ORCID]
Murzin D: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Pshenichnikov S: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
Kolesnikova VG: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Omelyanchik AS: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia [ORCID]
Gazvoda L: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
Spreitzer M: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
Panina L: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; College of New Materials and Nanotechnologies, National University of Science and Technology MISiS, 119991 Moscow, Russia
Rodionova V: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia; The Sophia Kovalevskaya North-West Center for Mathematical Research Center, Immanuel Kant Baltic Federal University, 236016 K [ORCID]
Vukomanović M: Advanced Materials Department, Jozef Stefan Institute, 1000 Ljubljana, Slovenia [ORCID]
Levada K: Institute of Physics Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, Russia
Journal Name
Processes
Volume
9
Issue
12
First Page
2264
Year
2021
Publication Date
2021-12-16
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9122264, Publication Type: Journal Article
Record Map
Published Article
LAPSE:2023.4320
This Record
External Link
https://doi.org/10.3390/pr9122264
Publisher Version
Download
Meta
Record Statistics
Record Views
344
Version History
[v1] (Original Submission)
Feb 22, 2023
Verified by curator on
Feb 22, 2023
This Version Number
v1
Citations
Most Recent
This Version
URL Here
https://psecommunity.org/LAPSE:2023.4320
Record Owner
Auto Uploader for LAPSE
Links to Related Works
(0.08 seconds)
[0.08 s]