Physical simulation is one of the effective methods to study mining problems, but the selection and proportion of simulation materials are greatly affected by the regional environment. This paper is based on a multilevel orthogonal design test scheme using sand, lime, and gypsum as the materials in the Shangwan coal mine in the Shendong coalfield, with the sand to cement ratio, paste to ash ratio, and maintenance days as variables. The effect of the polar difference method on the strength and density of gypsum was used as a reference for physical simulation in the Shendong coalfield. The sensitivity analysis of each factor was carried out by the polar difference method, and the influencing factors on density were, in descending order, sand to mortar ratio, mortar to ash ratio, and the number of maintenance days; the influencing factors on strength were, in descending order, mortar to ash ratio, maintenance days, and sand to mortar ratio. The sand cement ratio was negatively correlated with strength and density, the paste to ash ratio was positively correlated with strength and density, and the number of maintenance days was positively correlated with strength and negatively correlated with density. The multivariate non-linear regression analysis of sand to cement ratio and paste to ash ratio identified similar material proportioning test equations for the Shendong coalfield, which can improve the accuracy of physical simulation and be used to guide physical simulation experiments in the Shendong coalfield.