Human Cartilage Biomechanics: Experimental and Theoretical Approaches towards the Identification of Mechanical Properties in Healthy and Osteoarthritic Conditions

Elisa Belluzzi; Silvia Todros; Assunta Pozzuoli; Pietro Ruggieri; Emanuele Luigi Carniel; Alice Berardo

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2023.35092

Published Article

LAPSE:2023.35092

Human Cartilage Biomechanics: Experimental and Theoretical Approaches towards the Identification of Mechanical Properties in Healthy and Osteoarthritic Conditions

Elisa Belluzzi, Silvia Todros, Assunta Pozzuoli, Pietro Ruggieri, Emanuele Luigi Carniel, Alice Berardo

April 28, 2023

Articular cartilage is a complex connective tissue with the fundamental functions of load bearing, shock absorption and lubrication in joints. However, traumatic events, aging and degenerative pathologies may affect its structural integrity and function, causing pain and long-term disability. Osteoarthritis represents a health issue, which concerns an increasing number of people worldwide. Moreover, it has been observed that this pathology also affects the mechanical behavior of the articular cartilage. To better understand this correlation, the here proposed review analyzes the physiological aspects that influence cartilage microstructure and biomechanics, with a special focus on the pathological changes caused by osteoarthritis. Particularly, the experimental data on human articular cartilage are presented with reference to different techniques adopted for mechanical testing and the related theoretical mechanical models usually applied to articular cartilage are briefly discussed.

Record ID

LAPSE:2023.35092

Keywords

biomechanics, cartilage, constitutive modeling, experimental tests, osteoarthritis

Subject

System Identification

Suggested Citation

Belluzzi E, Todros S, Pozzuoli A, Ruggieri P, Carniel EL, Berardo A. Human Cartilage Biomechanics: Experimental and Theoretical Approaches towards the Identification of Mechanical Properties in Healthy and Osteoarthritic Conditions. (2023). LAPSE:2023.35092

Author Affiliations

Belluzzi E: Musculoskeletal Pathology and Oncology Laboratory, Department of Surgery, Oncology and Gastroenterology, DiSCOG, University of Padova, 35128 Padova, Italy; Orthopedics and Orthopedic Oncology, DiSCOG, University of Padova, 35128 Padova, Italy; Centre for [ORCID]
Todros S: Centre for Mechanics of Biological Materials, University of Padova, 35131 Padova, Italy; Department of Industrial Engineering, University of Padova, 35131 Padova, Italy [ORCID]
Pozzuoli A: Musculoskeletal Pathology and Oncology Laboratory, Department of Surgery, Oncology and Gastroenterology, DiSCOG, University of Padova, 35128 Padova, Italy; Orthopedics and Orthopedic Oncology, DiSCOG, University of Padova, 35128 Padova, Italy; Centre for [ORCID]
Ruggieri P: Orthopedics and Orthopedic Oncology, DiSCOG, University of Padova, 35128 Padova, Italy; Centre for Mechanics of Biological Materials, University of Padova, 35131 Padova, Italy [ORCID]
Carniel EL: Centre for Mechanics of Biological Materials, University of Padova, 35131 Padova, Italy; Department of Industrial Engineering, University of Padova, 35131 Padova, Italy [ORCID]
Berardo A: Centre for Mechanics of Biological Materials, University of Padova, 35131 Padova, Italy; Department of Civil, Environmental and Architectural Engineering, University of Padova, 35131 Padova, Italy; Department of Biomedical Sciences, University of Padova, [ORCID]

Journal Name

Processes

Volume

11

Issue

4

First Page

1014

Year

2023

Publication Date

2023-03-27