For the sake of understanding the mechanism of deep subcriticality and high heterogeneity of neutron fluence rate in time−space on the neutron kinetics of the Accelerator-driven Subcritical Reactor Subcritical Reactor (ADSR) under varied beam transients and neutron spectra. A Monte Carlo homogenization approach for the neutron time−space kinetics of the ADSR is proposed in this study, and the influence mechanism on the kinetic parameters of the ADSR under varied neutron spectra, subcriticality, and beam transients is examined. The results show that the Monte Carlo homogenization for the α eigenvalue mode is more adaptable to the subcriticality characteristics under varied subcriticality; under beam transients, the relative differences in the kinetic parameters of the different modes of the ADSR with fast/thermal spectra increase with the depth of subcriticality, and the differences in neutron generation time for varied modes are larger than those of effective fraction of delayed neutron. Thus, it is recommended to use a more adaptable Monte Carlo homogenization method for the time−space kinetics of ADSR, and the effects of the high heterogeneity of neutron fluence rate and deep subcriticality in time−space on the neutron generation time should be considered.