This paper addresses the analysis of the applicability of water as a working fluid for the new adsorptive heat transformation (AHT) cycle "Heat from Cold" (HeCol). The cycle proposed for cold countries operates at the ambient temperature below 0 °C. In this work, an aqueous solution of calcium chloride is proposed instead of liquid water to prevent the ice formation in the evaporator and condenser. The proposed water-based cycle is compared with the common methanol-based HeCol one in terms of the specific useful heat generated per cycle. The effect of the CaCl2 solution on the cycle boundary pressures and its useful heat is studied both theoretically and experimentally. This approach can be extended to other adsorptive heat transformation cycles working at an evaporator or condenser temperature below 0 °C.