Due to the excellent impact resistant performance of steel-plate concrete (SC) structure compared with the conventional reinforced concrete (RC) structure, SC structure is preferred to be used in the design of external walls of nuclear island buildings for new nuclear power plants (NPPs). This study aims at evaluating the effect of material and geometric parameters of SC containment on its impact resistant performance, thus the numerical simulation and sensitivity analysis of SC containment subjected to malicious large commercial aircraft attack are conducted based on the force time-history analysis method. The results show that: (1) the impact resistant performance of full SC containment is better than that of half SC containment; (2) for relatively thin full SC containment, the impact response and concrete damage can be significantly reduced by the enhancing of concrete strength grade or the increasing of steel plate thickness; (3) for the thicker full SC containment, concrete strength grade has only a slight influence on the impact displacement response, and the increasing of steel plate thickness has no significant effect on mitigating the impact displacement response. However, the increasing of steel plate thickness can effectively reduce its plastic strain, and the decreasing of strength grade of steel plate may obviously increase its plastic strain; and (4) concrete thickness plays a decisive role on the improvement of impact resistance, which is more effective than the enhancing of concrete strength grade. Resultantly, this paper provides a reference and guidance for the design of SC structure external walls of nuclear island buildings against a large commercial aircraft.