LAPSE:2023.3219
Published Article
LAPSE:2023.3219
Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles
February 22, 2023
Abstract
The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.
The elasticity of white blood cells (WBCs) provides valuable insight into the condition of the cells themselves, the presence of some diseases, as well as immune system activity. In this work, we describe a novel process of refined control of WBCs’ elasticity through a combined use of gold nanoparticles (AuNPs) and the microelectrode array device. The capture and controlled deformation of gold nanoparticles enriched white blood cells in vitro are demonstrated and quantified. Gold nanoparticles enhance the effect of electrically induced deformation and make the DEP-related processes more controllable.
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Keywords
electrodeformation, lab-on-chip, leukocytes, nanoparticles, Young’s modulus
Subject
Suggested Citation
Hallfors NG, Teo JCM, Bertone PM, Joshi CP, Orozaliev A, Martin MN, Isakovic AF. Electrodeformation of White Blood Cells Enriched with Gold Nanoparticles. (2023). LAPSE:2023.3219
Author Affiliations
Hallfors NG: Biomedical Engineering Department, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates [ORCID]
Teo JCM: Mechanical and Biomedical Engineering Department, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates [ORCID]
Bertone PM: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physics and Astronomy, Colgate University, Hamilton, NY 13346, USA [ORCID]
Joshi CP: Physics Department, Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates
Orozaliev A: Mechanical and Biomedical Engineering Department, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates
Martin MN: Physics Department, Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates
Isakovic AF: Department of Physics and Astronomy, Colgate University, Hamilton, NY 13346, USA [ORCID]
Teo JCM: Mechanical and Biomedical Engineering Department, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates [ORCID]
Bertone PM: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physics and Astronomy, Colgate University, Hamilton, NY 13346, USA [ORCID]
Joshi CP: Physics Department, Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates
Orozaliev A: Mechanical and Biomedical Engineering Department, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates
Martin MN: Physics Department, Khalifa University, Abu Dhabi, P.O. Box 127788, United Arab Emirates
Isakovic AF: Department of Physics and Astronomy, Colgate University, Hamilton, NY 13346, USA [ORCID]
Journal Name
Processes
Volume
10
Issue
1
First Page
134
Year
2022
Publication Date
2022-01-10
ISSN
2227-9717
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Original Submission
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PII: pr10010134, Publication Type: Journal Article
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Published Article
LAPSE:2023.3219
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External Link
https://doi.org/10.3390/pr10010134
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Feb 22, 2023
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Feb 22, 2023
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