This study aims to investigate the thermal performance of PCM and PCM combined with nighttime natural (NV) and mechanical ventilation (MV) applied to a residential building located in eight cities of tropical rainforest climate zone (Af). The analysis was accomplished using numerical simulations and developing a unique methodology for selecting the PCM melting temperature based on the thermal comfort limits. The thermal performance of the PCM integrated building was quantitatively evaluated using the concept of peak temperature drop. Additionally, a novel indicator of Total Temperature Drop (TTD) was introduced to determine the overall impact of the PCM and PCM combined with NV/MV on the thermal comfort conditions inside the building. The results showed that PCM 28 was the most efficient in improving the thermal performance of the building located in the Af climate zone, achieving a TTD of up to 356 °C per year. The usage of PCM 28 combined with nighttime natural ventilation improved the TTD values by up to 15%, whereas the integration of PCM 28 combined with mechanical ventilation resulted in a TTD values increase of up to 45%. Conclusively, mechanical ventilation showed its superiority over natural ventilation in the tropical rainforest climate, and PCM 28 applied together with mechanical ventilation could be used as the optimum combination for the whole climate zone.