LAPSE:2023.28309
Published Article
LAPSE:2023.28309
Novel Non-Toxic Highly Antibacterial Chitosan/Fe(III)-Based Nanoparticles That Contain a Deferoxamine—Trojan Horse Ligands: Combined Synthetic and Biological Studies
April 11, 2023
Abstract
In this study, we prepared chitosan/Fe(III)/deferoxamine nanoparticles with unimodal size distribution (hydrodynamic diameter ca. 250 nm, zeta potential ca. 32 mV). The elaborated nanoparticles are characterized by outstanding in vitro and in vivo antibacterial activity, which exceeds even that of commercial antibiotics ampicillin and gentamicin. Moreover, the nanoparticles are non-toxic. We found that the introduction of iron ions into the chitosan matrix increases the ability of the resulting nanoparticles to disrupt the integrity of the membranes of microorganisms in comparison with pure chitosan. The introduction of deferoxamine into the obtained nanoparticles sharply expands their effect of destruction the bacterial membrane. The obtained antibacterial nanoparticles are promising for further preclinical studies.
In this study, we prepared chitosan/Fe(III)/deferoxamine nanoparticles with unimodal size distribution (hydrodynamic diameter ca. 250 nm, zeta potential ca. 32 mV). The elaborated nanoparticles are characterized by outstanding in vitro and in vivo antibacterial activity, which exceeds even that of commercial antibiotics ampicillin and gentamicin. Moreover, the nanoparticles are non-toxic. We found that the introduction of iron ions into the chitosan matrix increases the ability of the resulting nanoparticles to disrupt the integrity of the membranes of microorganisms in comparison with pure chitosan. The introduction of deferoxamine into the obtained nanoparticles sharply expands their effect of destruction the bacterial membrane. The obtained antibacterial nanoparticles are promising for further preclinical studies.
Record ID
Keywords
antibacterial activity, chitosan, deferoxamine, iron(III), nanoparticles, toxicity
Subject
Suggested Citation
Khubiev OM, Esakova VE, Egorov AR, Bely AE, Golubev RA, Tachaev MV, Kirichuk AA, Lobanov NN, Tskhovrebov AG, Kritchenkov AS. Novel Non-Toxic Highly Antibacterial Chitosan/Fe(III)-Based Nanoparticles That Contain a Deferoxamine—Trojan Horse Ligands: Combined Synthetic and Biological Studies. (2023). LAPSE:2023.28309
Author Affiliations
Khubiev OM: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia [ORCID]
Esakova VE: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Egorov AR: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia [ORCID]
Bely AE: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Golubev RA: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia; Metal Physics Laboratory, Institute of Technical Acoustics NAS of Belarus, 210009 Vitebsk, Belarus
Tachaev MV: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Kirichuk AA: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Lobanov NN: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Tskhovrebov AG: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia [ORCID]
Kritchenkov AS: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia; Metal Physics Laboratory, Institute of Technical Acoustics NAS of Belarus, 210009 Vitebsk, Belarus [ORCID]
Esakova VE: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Egorov AR: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia [ORCID]
Bely AE: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Golubev RA: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia; Metal Physics Laboratory, Institute of Technical Acoustics NAS of Belarus, 210009 Vitebsk, Belarus
Tachaev MV: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Kirichuk AA: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Lobanov NN: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia
Tskhovrebov AG: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia [ORCID]
Kritchenkov AS: Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia; Metal Physics Laboratory, Institute of Technical Acoustics NAS of Belarus, 210009 Vitebsk, Belarus [ORCID]
Journal Name
Processes
Volume
11
Issue
3
First Page
870
Year
2023
Publication Date
2023-03-14
ISSN
2227-9717
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PII: pr11030870, Publication Type: Journal Article
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LAPSE:2023.28309
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https://doi.org/10.3390/pr11030870
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Apr 11, 2023
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