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LAPSE:2023.22799

Evaluation of Wound Healing Potential of Novel Hydrogel Based on Ocimum basilicum and Trifolium pratense Extracts

Ina Andreea Antonescu (Mintaș), Angela Antonescu, Florina Miere (Groza), Luminița Fritea, Alin Cristian Teușdea, Laura Vicaș, Simona Ioana Vicaș, Ilarie Brihan, Maria Domuța, Mihaela Zdrinca, Marcel Zdrinca, Simona Cavalu

March 24, 2023

Abstract
Plants are an inexhaustible source of compounds with different medicinal properties, suitable as alternative options for the prevention and treatment of various pathologies. They are safe, effective and economical. In this paper, a combined extract made of Ocimum basilicum and Trifolium pratense extracts (EOT) was used for the first time to demonstrate its healing effect on dermal pathologies. To evaluate the wound healing effect of EOT, a novel gel formulation was prepared and subsequently tested in vitro (using the scratch test assay) and in vivo (on an animal model). The in vitro tests demonstrated the complete recovery of the dermal fibroblast monolayer when treated with EOT in a concentration of 50 µg/mL. In vivo results using a hydrogel formulation based on EOT demonstrated improved wound contraction time and complete healing after 13 days of treatment. Moreover, a clinical case of Psoriasis vulgaris was presented, in which one week of treatment led to the significant improvement of the patient’s health. In conclusion, the topical use of the novel gel formulation containing EOT is a successful therapeutic alternative in the treatment of dermal diseases.

Record ID

LAPSE:2023.22799

Keywords

hydrogel, in vitro and in vivo tests, Ocimum basilicum, Psoriasis vulgaris, scratch assay, Trifolium pratense

Subject

Materials

Suggested Citation

Antonescu (Mintaș) IA, Antonescu A, Miere (Groza) F, Fritea L, Teușdea AC, Vicaș L, Vicaș SI, Brihan I, Domuța M, Zdrinca M, Zdrinca M, Cavalu S. Evaluation of Wound Healing Potential of Novel Hydrogel Based on Ocimum basilicum and Trifolium pratense Extracts. (2023). LAPSE:2023.22799

Author Affiliations

Antonescu (Mintaș) IA: Faculty of Medicine and Pharmacy, Doctoral School of Biomedical Science, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Antonescu A: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Miere (Groza) F: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Fritea L: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Teușdea AC: Faculty of Environmental Protection, University of Oradea, 26 Gen. Magheru Street, 410048 Oradea, Romania
Vicaș L: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania [ORCID]
Vicaș SI: Faculty of Environmental Protection, University of Oradea, 26 Gen. Magheru Street, 410048 Oradea, Romania
Brihan I: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Domuța M: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Zdrinca M: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Zdrinca M: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania
Cavalu S: Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania [ORCID]

Journal Name

Processes

Volume

Issue

First Page

2096

Year

2021

Publication Date

2021-11-22

DOI:

https://doi.org/10.3390/pr9112096