Liquefied natural gas has attracted attention through an explosive increase in demands and environmental requirements. During this period, the Energy Efficiency Design Index (EEDI), which was adopted by the International Maritime Organization, expecting to significantly reduce CO2 from ships, has become an important key. It has triggered a change in use from steam turbine systems and dual fuel diesel electrics to high-efficiency main engines such as ME-GI engines to meet the EEDI requirements. However, since the ME-GI engines use 300 bar of fuel gas pressure, it is necessary to resolve problems of the pressure controllability and to prevent the reductions of the re-liquefaction amount caused by clogging of the lubricant mixed with the fuel gas during the compression. The purpose of this study is to propose a novel control strategy with a newly developed configuration for controlling the pressure so as not to trip the BOG compressors when the ME-GI engines are tripped, and for preventing a reduction on re-liquefaction amount. Unlike the typical configuration used in the current vessels, this proposal separately provides the fuel gas at 150 bar without lubricants to the re-liquefaction. In addition, three control strategies are proposed, depending upon the application of multi-controllers and the location of the pressure transmitters. A simulation was conducted to verify the efficacy of the proposed method, focusing on the controllability of the pressure and the re-liquefaction amount, in comparison with the typical configuration. As results of the simulation, the proposal showed excellent controllability without trips of the BOG compressors even in abnormal conditions and confirmed the great re-liquefaction performance.