LAPSE:2023.1547
Published Article
LAPSE:2023.1547
Thermal Degradation Process of Ethinylestradiol—Kinetic Study
February 21, 2023
Abstract
The present study reports the results obtained after the analysis of the thermal stability and decomposition kinetics of widely used synthetic derivative of estradiol, ethinylestradiol (EE), as a pure active pharmaceutical ingredient. As investigational tools, Fourier transformed infrared spectroscopy (FTIR), thermal analysis, and decomposition kinetics modeling of EE were employed. The kinetic study was realized using three kinetic methods, namely Kissinger, Friedman, and Flynn-Wall-Ozawa. The results of the kinetic study are in good agreement, suggesting that the main decomposition process of EE that takes place in the 175−375 °C temperature range is a single-step process, invariable during the modification of heating rate of the sample.
The present study reports the results obtained after the analysis of the thermal stability and decomposition kinetics of widely used synthetic derivative of estradiol, ethinylestradiol (EE), as a pure active pharmaceutical ingredient. As investigational tools, Fourier transformed infrared spectroscopy (FTIR), thermal analysis, and decomposition kinetics modeling of EE were employed. The kinetic study was realized using three kinetic methods, namely Kissinger, Friedman, and Flynn-Wall-Ozawa. The results of the kinetic study are in good agreement, suggesting that the main decomposition process of EE that takes place in the 175−375 °C temperature range is a single-step process, invariable during the modification of heating rate of the sample.
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Keywords
degradation, ethinylestradiol, isoconversional kinetics, thermal stability
Subject
Suggested Citation
Simu S, Ledeţi A, Moacă EA, Păcurariu C, Dehelean C, Navolan D, Ledeţi I. Thermal Degradation Process of Ethinylestradiol—Kinetic Study. (2023). LAPSE:2023.1547
Author Affiliations
Simu S: Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Ledeţi A: Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Moacă EA: Research Centre for Pharmaco-Toxicological Evaluation, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Păcurariu C: Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timisoara, 2 Victoriei Square, 300006 Timisoara, Romania
Dehelean C: Research Centre for Pharmaco-Toxicological Evaluation, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Navolan D: Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Ledeţi I: Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Ledeţi A: Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Moacă EA: Research Centre for Pharmaco-Toxicological Evaluation, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Păcurariu C: Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timisoara, 2 Victoriei Square, 300006 Timisoara, Romania
Dehelean C: Research Centre for Pharmaco-Toxicological Evaluation, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Navolan D: Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Ledeţi I: Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania [ORCID]
Journal Name
Processes
Volume
10
Issue
8
First Page
1518
Year
2022
Publication Date
2022-08-02
ISSN
2227-9717
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Original Submission
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PII: pr10081518, Publication Type: Journal Article
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LAPSE:2023.1547
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https://doi.org/10.3390/pr10081518
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Feb 21, 2023
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