Abstract
Domoic acid (DA) is a neurotoxin mainly produced by Pseudo-nitzschia diatom, which belongs to the genera Rhomboida. It can combine with the receptors of glutamate of neurotransmitters, then affecting the normal nerve signal transmission of the organism and causing nervous system disorders. However, as a natural marine drug, DA can also be used for pest prevention and control. Although the distribution of DA in the world has already been reported in the previous reviews, the time and location of its first discovery and the specific information are not complete. Therefore, the review systematically summarizes the first reported situation of DA in various countries (including species, discovery time, and collection location). Furthermore, we update and analyze the factors affecting DA production, including phytoplankton species, growth stages, bacteria, nutrient availability, trace metals, and so on. These factors may indirectly affect the growth environment or directly affect the physiological activities of the cells, then affect the production of DA. Given that DA is widely distributed in the environment, we summarize the main technical methods for the determination of DA, such as bioassay, high-performance liquid chromatography (HPLC), enzyme-linked immunosorbent assay (ELISA), biosensor, and so on, as well as the advantages and disadvantages of each method used so far, which adds more new knowledge in the literature about DA until now. Finally, the DA research forecast and its industrial applications were prospected to prevent its harm and fully explore its potential value.