LAPSE:2023.11482
Published Article
LAPSE:2023.11482
Menthol and Fatty Acid-Based Hydrophobic Deep Eutectic Solvents as Media for Enzyme Activation
February 27, 2023
Abstract
This research aims to provide insights into the biological efficacy of a newly formed hydrophobic deep eutectic solvent (DES). A DES based on menthol was successfully synthesized with fatty acids. The DESs’ properties as enzyme activators were examined against a neat counterpart. The menthol:decanoic acid (1:1) combination showed improved thermal stability, strong catalytic activity, and reusability for up to four subsequent cycles under ideal conditions (pH 7.0, 40 °C for 2 h). The hydrophobic DES replaced hexane in ester synthesis, where RNL@DES5 showed better fatty acid conversion compared to neat RNL. This study demonstrated promising applications of hydrophobic DESs in non-aqueous organic reactions.
This research aims to provide insights into the biological efficacy of a newly formed hydrophobic deep eutectic solvent (DES). A DES based on menthol was successfully synthesized with fatty acids. The DESs’ properties as enzyme activators were examined against a neat counterpart. The menthol:decanoic acid (1:1) combination showed improved thermal stability, strong catalytic activity, and reusability for up to four subsequent cycles under ideal conditions (pH 7.0, 40 °C for 2 h). The hydrophobic DES replaced hexane in ester synthesis, where RNL@DES5 showed better fatty acid conversion compared to neat RNL. This study demonstrated promising applications of hydrophobic DESs in non-aqueous organic reactions.
Record ID
Keywords
enzyme kinetics, fatty acid, hydrogen-bonding, hydrophobic agent, natural deep eutectic solvents
Subject
Suggested Citation
Elgharbawy AAM, Syed Putra SS, Khan HW, Azmi NAN, Sani MSA, Ab llah N, Hayyan A, Jewaratnam J, Basirun WJ. Menthol and Fatty Acid-Based Hydrophobic Deep Eutectic Solvents as Media for Enzyme Activation. (2023). LAPSE:2023.11482
Author Affiliations
Elgharbawy AAM: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia; Bioenvironmental Engineering Research Centre (BERC), Department of Biotechnology Engineering, Faculty of Engineering, [ORCID]
Syed Putra SS: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603, Malaysia
Khan HW: Chemical Engineering Department, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia; Center for Research in Ionic Liquids, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia
Azmi NAN: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia [ORCID]
Sani MSA: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia [ORCID]
Ab llah N: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia
Hayyan A: University Malaya Center for Ionic Liquids (UMCiL), Universiti Malaya, Kuala Lumpur 50603, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University Malaya, Kuala Lumpur 50603, Malaysia [ORCID]
Jewaratnam J: Center for Research in Ionic Liquids, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia [ORCID]
Basirun WJ: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603, Malaysia [ORCID]
Syed Putra SS: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603, Malaysia
Khan HW: Chemical Engineering Department, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia; Center for Research in Ionic Liquids, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia
Azmi NAN: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia [ORCID]
Sani MSA: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia [ORCID]
Ab llah N: International Institute of Halal Research and Training (INHART), International Islamic University Malaysia, Kuala Lumpur 53100, Malaysia
Hayyan A: University Malaya Center for Ionic Liquids (UMCiL), Universiti Malaya, Kuala Lumpur 50603, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University Malaya, Kuala Lumpur 50603, Malaysia [ORCID]
Jewaratnam J: Center for Research in Ionic Liquids, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Malaysia [ORCID]
Basirun WJ: Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603, Malaysia [ORCID]
Journal Name
Processes
Volume
11
Issue
2
First Page
547
Year
2023
Publication Date
2023-02-10
ISSN
2227-9717
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Original Submission
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PII: pr11020547, Publication Type: Journal Article
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LAPSE:2023.11482
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https://doi.org/10.3390/pr11020547
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Feb 27, 2023
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