LAPSE:2023.0919
Published Article
LAPSE:2023.0919
Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile
February 21, 2023
Abstract
Background: The fish-based diet is known for its potential health benefits, but it is less known for its association with mercury (Hg) exposure, which, in turn, can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress. The aim of this study was to evaluate the correlations between Hg blood concentration and specific biomarkers for oxidative stress. Methods: We present a cross-sectional, analytical, observational study, including primary quantitative data obtained from 67 patients who presented with unspecific complaints and had high levels of blood Hg. Oxidative stress markers, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MLD), lymphocyte glutathione (GSH-Ly), selenium (Se), and vitamin D were determined. Results: We found positive, strong correlations between Hg levels and SOD (r = 0.88, p < 0.0001), GPx (r = 0.92, p < 0.0001), and MLD (r = 0.94, p < 0.0001). We also found inverted correlations between GSH-Ly and vitamin D and Hg blood levels (r = −0.86, r = −0.91, respectively, both with p < 0.0001). Se had a weak correlation with Hg plasma levels, but this did not reach statistical significance (r = −0.2, p > 0.05). Conclusions: Thus, we can conclude that low-level Hg exposure can be an inductor of oxidative stress.
Background: The fish-based diet is known for its potential health benefits, but it is less known for its association with mercury (Hg) exposure, which, in turn, can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress. The aim of this study was to evaluate the correlations between Hg blood concentration and specific biomarkers for oxidative stress. Methods: We present a cross-sectional, analytical, observational study, including primary quantitative data obtained from 67 patients who presented with unspecific complaints and had high levels of blood Hg. Oxidative stress markers, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MLD), lymphocyte glutathione (GSH-Ly), selenium (Se), and vitamin D were determined. Results: We found positive, strong correlations between Hg levels and SOD (r = 0.88, p < 0.0001), GPx (r = 0.92, p < 0.0001), and MLD (r = 0.94, p < 0.0001). We also found inverted correlations between GSH-Ly and vitamin D and Hg blood levels (r = −0.86, r = −0.91, respectively, both with p < 0.0001). Se had a weak correlation with Hg plasma levels, but this did not reach statistical significance (r = −0.2, p > 0.05). Conclusions: Thus, we can conclude that low-level Hg exposure can be an inductor of oxidative stress.
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Keywords
low-level exposure, mercury, oxidative stress
Suggested Citation
Tincu RC, Cobilinschi C, Florea IA, Cotae AM, Băetu AE, Isac S, Ungureanu R, Droc G, Grintescu IM, Mirea L. Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile. (2023). LAPSE:2023.0919
Author Affiliations
Tincu RC: Clinical Toxicology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania
Cobilinschi C: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania [ORCID]
Florea IA: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania
Cotae AM: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Băetu AE: Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; “Grigore Alexandrescu” Clinical Emergency Hospital for Children, 011743 Bucharest, Romania
Isac S: Physiology, Functional Science, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; Fundeni Clinical Institute, 022328 Bucharest, Romania [ORCID]
Ungureanu R: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Droc G: Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; Fundeni Clinical Institute, 022328 Bucharest, Romania [ORCID]
Grintescu IM: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Mirea L: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Cobilinschi C: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania [ORCID]
Florea IA: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania
Cotae AM: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Băetu AE: Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; “Grigore Alexandrescu” Clinical Emergency Hospital for Children, 011743 Bucharest, Romania
Isac S: Physiology, Functional Science, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; Fundeni Clinical Institute, 022328 Bucharest, Romania [ORCID]
Ungureanu R: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Droc G: Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania; Fundeni Clinical Institute, 022328 Bucharest, Romania [ORCID]
Grintescu IM: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Mirea L: Bucharest Clinical Emergency Hospital, 014461 Bucharest, Romania; Anesthesiology, Department of Orthopedics and Anesthesiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Journal Name
Processes
Volume
10
Issue
11
First Page
2388
Year
2022
Publication Date
2022-11-14
ISSN
2227-9717
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Original Submission
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PII: pr10112388, Publication Type: Journal Article
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LAPSE:2023.0919
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https://doi.org/10.3390/pr10112388
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