Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

Md. Habibur Rahman; Johny Bajgai; Ailyn Fadriquela; Subham Sharma; Thuy Trinh Thi; Rokeya Akter; Seong Hoon Goh; Cheol-Su Kim; Kyu-Jae Lee

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2022.0160

Published Article

LAPSE:2022.0160

Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

Md. Habibur Rahman, Johny Bajgai, Ailyn Fadriquela, Subham Sharma, Thuy Trinh Thi, Rokeya Akter, Seong Hoon Goh, Cheol-Su Kim, Kyu-Jae Lee

December 6, 2022

Oxidative stress (OS) and neuroinflammatory stress affect many neurological disorders. Despite the clinical significance of oxidative damage in neurological disorders, still, no effective and safe treatment methods for neuro diseases are available. With this, molecular hydrogen (H2) has been recently reported as an antioxidant and anti-inflammatory agent to treat several oxidative stress-related diseases. In animal and human clinical trials, the routes for H2 administration are mainly categorized into three types: H2 gas inhalation, H2 water dissolving, and H2-dissolved saline injection. This review explores some significant progress in research on H2 use in neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, neonatal disorders of the brain, and other NDs (retinal ischemia and traumatic brain injury). Even though most neurological problems are not currently curable, these studies have shown the therapeutic potential for prevention, treatment, and mitigation of H2 administration. Several possible H2-effectors, including cell signaling molecules and hormones, which prevent OS and inflammation, will also be addressed. However, more clinical and other related studies are required to evaluate the direct H2 target molecule.

Record ID

LAPSE:2022.0160

Keywords

antioxidant, inflammation, molecular hydrogen, neurological disorder, neuroprotection, oxidative stress

Subject

Other

Suggested Citation

Rahman MH, Bajgai J, Fadriquela A, Sharma S, Trinh Thi T, Akter R, Goh SH, Kim CS, Lee KJ. Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases. (2022). LAPSE:2022.0160

Author Affiliations

Rahman MH: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea; Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea [ORCID]
Bajgai J: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea [ORCID]
Fadriquela A: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea [ORCID]
Sharma S: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea; Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
Trinh Thi T: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea; Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
Akter R: Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
Goh SH: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
Kim CS: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
Lee KJ: Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea

Journal Name

Processes

Volume

9

Issue

2

First Page

308

Year

2021

Publication Date

2021-02-06