LAPSE:2022.0117
Published Article
LAPSE:2022.0117
Spray Drying for Direct Compression of Pharmaceuticals
Nizar Al-Zoubi, Shadi Gharaibeh, Ahmad Aljaberi, Ioannis Nikolakakis
October 31, 2022
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.
Keywords
active pharmaceutical ingredient, co-processing, direct compression, excipient, multifunctional, oral disintegration, spray drying, sustained release, tablets
Subject
Suggested Citation
Al-Zoubi N, Gharaibeh S, Aljaberi A, Nikolakakis I. Spray Drying for Direct Compression of Pharmaceuticals. (2022). LAPSE:2022.0117
Author Affiliations
Al-Zoubi N: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa 13133, Jordan
Gharaibeh S: Faculty of Pharmacy, Jerash University, Jerash 26150, Jordan [ORCID]
Aljaberi A: Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan
Nikolakakis I: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece [ORCID]
Journal Name
Processes
Volume
9
Issue
2
First Page
267
Year
2021
Publication Date
2021-01-30
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9020267, Publication Type: Review
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LAPSE:2022.0117
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doi:10.3390/pr9020267
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Oct 31, 2022
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CC BY 4.0
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Version History
[v1] (Original Submission)
Oct 31, 2022
 
Verified by curator on
Oct 31, 2022
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v1
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https://psecommunity.org/LAPSE:2022.0117
 
Original Submitter
Mina Naeini
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