LAPSE:2020.1271
Published Article
LAPSE:2020.1271
Targeting Collagen Type III in Proteinuric Kidney Disease: Informing Drug Potential Using the Jaccard−Tanimoto Index
Michelle Liu, Anoushka Dalvi, Sony Dalapati, Natalia Prakash, Zhijian Hu, Ping Zhou, Kai Jiang, Anthony Pellicano, Itzhak D. Goldberg, Prakash Narayan
December 22, 2020
Collagenofibrotic glomerulopathy, a collagen type III kidney disease, is associated with proteinuria and accumulation ofcollagen type III in the glomerulus specifically the mesangium and/or capillary walls. The puromcyin aminonucleoside (PAN) nephropathy model was evaluated to examine the relation between COL3A1 mRNA and proteinuria. In Wistar rats administered PAN, a robust increase in proteinuria was accompanied by glomerular hypertrophy and expansion of both the Bowman’s capsule and Bowman’s space. An ~4-fold increase in renal COL3A1 mRNA was observed in the PAN cohort with urine protein exhibiting a direct (r = 0.8) and significant correlation with kidney COL3A1 mRNA level. Both Picrosirius red polarized microscopy and immunohistochemical analysis showed localization of collagen type III to the glomerular mesangium. Gene ontology-driven transcriptomic analysis reveals a robust COL3A1 network in the glomerular compartment.
Keywords
collagen type III, discovery, drug, glomerulus, kidney, medicine, precision, proteinuria, transcriptomic
Subject
Suggested Citation
Liu M, Dalvi A, Dalapati S, Prakash N, Hu Z, Zhou P, Jiang K, Pellicano A, Goldberg ID, Narayan P. Targeting Collagen Type III in Proteinuric Kidney Disease: Informing Drug Potential Using the Jaccard−Tanimoto Index. (2020). LAPSE:2020.1271
Author Affiliations
Liu M: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Dalvi A: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Dalapati S: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Prakash N: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Hu Z: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Zhou P: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Jiang K: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Pellicano A: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Goldberg ID: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Narayan P: Department of Preclinical Research, Angion Biomedica Corp., 51 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Journal Name
Processes
Volume
8
Issue
8
Article Number
E996
Year
2020
Publication Date
2020-08-16
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8080996, Publication Type: Journal Article
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LAPSE:2020.1271
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doi:10.3390/pr8080996
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Dec 22, 2020
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CC BY 4.0
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Dec 22, 2020
 
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Original Submitter
Calvin Tsay
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