LAPSE:2021.0788
Published Article
LAPSE:2021.0788
Dynamic Modelling of T Cell Vaccination Response
Alisa Douglas, Thomas A Adams II, David A Christian
October 21, 2021
In our previous work, a mathematical, agent-based dynamic model was developed which simulates the response of the mammalian omentum to a T cell vaccine injection during the expansion phase. The model tracks how each individual naïve T cell interacts with antigen presenting cells, and subsequently primes and divides over an 8-day period following vaccine injection. The model works from first principles; individual phenomena based on experimental observation and theory are incorporated into the model, and the collection of many such phenomena together create a nuanced model of the system as a whole. In this work, we show that the model works well in other relevant tissues, such as the spleen.
Keywords
Dynamic Modelling, stochastic modelling, T cells, vaccine
Subject
Suggested Citation
Douglas A, Adams TA II, Christian DA. Dynamic Modelling of T Cell Vaccination Response. (2021). LAPSE:2021.0788
Author Affiliations
Douglas A: McMaster University
Adams TA II: McMaster University [ORCID] [Google Scholar]
Christian DA: University of Pennsylvania
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Journal Name
CSChE Systems & Control Transactions
Volume
1
First Page
6
Last Page
10
Year
2021
Publication Date
2021-10-21
Version Comments
Original Submission
Other Meta
Proceedings of the Canadian Chemical Engineering Conference 2021, October 24-27, Montréal, Québec, Canada
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Oct 21, 2021
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CC BY-SA 4.0
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Oct 21, 2021
 
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