Dynamic Modelling of T Cell Vaccination Response
October 21, 2021
In our previous work, a mathematical, agent-based dynamic model was developed which simulates the response of the mammalian omentum to a T cell vaccine injection during the expansion phase. The model tracks how each individual naïve T cell interacts with antigen presenting cells, and subsequently primes and divides over an 8-day period following vaccine injection. The model works from first principles; individual phenomena based on experimental observation and theory are incorporated into the model, and the collection of many such phenomena together create a nuanced model of the system as a whole. In this work, we show that the model works well in other relevant tissues, such as the spleen.
Dynamic Modelling, stochastic modelling, T cells, vaccine
Douglas A, Adams TA II, Christian DA. Dynamic Modelling of T Cell Vaccination Response. (2021). LAPSE:2021.0788
CSChE Systems & Control Transactions
Proceedings of the Canadian Chemical Engineering Conference 2021, October 24-27, Montréal, Québec, Canada