As a type of airtight conveying mode, pneumatic conveying has the advantages of environmental friendliness and conveying without dust overflow. The application of the pneumatic conveying system in the field of coal particle conveying can avoid direct contact between coal particles and the atmosphere, which helps to reduce the concentration of air dust and improve environmental quality in coal production and coal consumption enterprises. In order to predict pressure drop in the pipe during the horizontal pneumatic conveying of large coal particles, the Lagrangian coupling method and DPM (discrete particle model) simulation model was used in this paper. Based on the comparison of the experimental results, the feasibility of the simulation was verified and the pressure drop in the pipe was simulated. The simulation results show that when the flow velocity is small, the simulation results of the DPM model are quite different from that of the experiment. When the flow velocity is large, the large particle horizontal pneumatic conveying behavior predicted by the model is feasible, which can provide a simulation reference for the design of the coal pneumatic conveying system.