The present work is a computational investigation of nanofluid and hybrid nanofluid transport in a periodic structure. The governing equations for this work along with the appropriate boundary conditions are solved using the finite-volume method. The simulations are carried out using five wavy amplitudes of the channel shape for a range of Reynolds numbers from 102 to103. It is found that increasing the amplitude and increasing the nanoparticle volume fraction achieve enhancement of the heat transfer at the cost of increased pumping power. Correlations for the friction factor and the Nusselt number for both fluid types are provided.