To investigate the deformation-failure process of Longmaxi shale under uniaxial compression conditions from the mesoscopic and macroscopic points of view, novel X-ray microComputed Tomography (micro-CT) equipment combined with unique loading apparatus was used. Cylindrical shale samples (4 mm in diameter and 8 mm in height) were produced to perform a series of uniaxial compression tests. CT scanning images at different time points during the loading process were obtained to study the characteristics of the progressive failure. In addition, stereograms were reconstructed and vertical slices were selected to explain the failure mechanism. From the results of the testing the low-density area, local per-peak cracks, numerous post-peak cracks and secondary cracks consecutively appeared in the CT images. Vertical and inclined fissures in the samples could be observed from the stereograms’ surfaces and from internal slices. The cracking indicates that the failure process of shale is progressive and the failure mechanism of shale under uniaxial compression is mainly tension destruction or comprehensive tension-shear destruction.