LAPSE

LAPSE:2019.1318
Published Article
LAPSE:2019.1318
Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers
Federico Perche
December 10, 2019
The integration of drugs into nanocarriers favorably altered their pharmacodynamics and pharmacokinetics compared to free drugs, and increased their therapeutic index. However, selective cellular internalization in diseased tissues rather than normal tissues still presents a formidable challenge. In this chapter I will cover solutions involving environment-responsive cell-penetrating peptides (CPPs). I will discuss properties of CPPs as universal cellular uptake enhancers, and the modifications imparted to CPP-modified nanocarriers to confine CPP activation to diseased tissues.
Keywords
cellular uptake, peptides, responsive
Subject
Suggested Citation
Perche F. Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers. (2019). LAPSE:2019.1318
Author Affiliations
Perche F: Centre de Biophysique Moléculaire, UPR CNRS 4301, Rue Charles Sadron, Orléans, 45071 CEDEX 2, France
Journal Name
Processes
Volume
7
Issue
10
Article Number
E727
Year
2019
Publication Date
2019-10-11
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7100727, Publication Type: Review
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LAPSE:2019.1318
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doi:10.3390/pr7100727
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Dec 10, 2019
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CC BY 4.0
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[v1] (Original Submission)
Dec 10, 2019
 
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Dec 10, 2019
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http://psecommunity.org/LAPSE:2019.1318
 
Original Submitter
Calvin Tsay
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