In order to obtain the structural intensity under the operation conditions of MSP (molten salt pump), the rotor component of MSP is taken as the research object. In this paper, the influence of material properties change on the structural performance of MSP at different temperatures is analyzed. The stress distribution and strain distribution of MSP rotor components under different loads are investigated, and the intensity calculation of MSP rotor system is carried out to explore whether it meets the intensity requirements under high temperature operation, which lays a foundation for the high temperature test of MSP. The results show that the maximum deformation position of the blade working face appears at the outer edge of the impeller. When the fluid-structure coupling is applied, the blade strain law and the strain law during thermo-coupling are similar. The effect of the temperature field on the degree of blade deformation is not significant, provided that other factors remain the same. The position where the impeller equivalent stress is the largest is mainly concentrated in the area where the blade is in contact with the front and rear cover plates at the outlet of the impeller. Different degrees of stress concentration occur in the area where the blade is in contact with the impeller hub. The distribution law of the equivalent stress on the surface of the impeller cover plate is that the equivalent stress value changes periodically along the circumferential direction of the impeller, and the number of change cycles is equal to the number of impeller blades. This study can provide a reference for the structural design of MSPs.