With the rapid development of industrial technology, the multi-point (multi-input multi-output) heating processing systems with integrated temperature control have been increasingly needed to achieve high-quality and high-performance processing. In this paper, in response to the demand for proper transient response and to provide more accurate temperature controls, a novel pole-zero cancelation method is proposed for multi-input multi-output (MIMO) temperature control in heating process systems. In the proposed method, the temperature differences and transient characteristics of all points can be improved by compensating dead time difference and coupling effect together by matrix compensation and pole-zero cancelation with the feedforward reference model. Both simulations and experiments were carried out. The results were compared to the well-tuned conventional PI control system and PI plus decoupling compensation system to evaluate the control efficiency of the proposed method.