Air high in humidity leads to uncomfortable conditions and promotes the growth of different fungi and bacteria, which may cause health problems. The control of moisture content in the air using traditional air conditioning techniques is not a suitable option due to large consumption of primary energy and hence emission of greenhouse gases. The evaporative cooling technology is a cost effective and eco-friendly alternative but can provide thermal comfort conditions only under low humidity conditions. However, the evaporative cooling method can be used effectively in conjunction with desiccant dehumidifiers for better control of humidity. Such systems can control the temperature and humidity of the air independently and can effectively utilize the low-grade thermal energy resources. In this paper, the theoretical analysis of desiccant based evaporative cooling systems is carried out for five cities in Saudi Arabia (Jeddah, Jazan, Riyadh, Hail, and Dhahran). It has been observed that the coefficient of performance (COP) of the system varies from 0.275 to 0.476 for different locations. The water removal capacity of the desiccant wheel is at its maximum for the climatic conditions of Jazan and at its minimum for Hail. The effect of climatic conditions of five cities on regeneration temperature, air mass flow rate, and potential of solar energy has been evaluated using RET Screen software.