Aza-Michael Additions of Benzylamine to Acrylates Promoted by Microwaves and Conventional Heating Using DBU as Catalyst via Solvent-Free Protocol

Leticia Chavelas-Hernández; Luis G. Hernández-Vázquez; José D. Bahena-Martínez; Alexa B. Arroyo-Colín; Sinuhe G. Flores-Osorio; Gabriel Navarrete-Vázquez; Jaime Escalante

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2024.1323v1

Published Article

LAPSE:2024.1323v1

Aza-Michael Additions of Benzylamine to Acrylates Promoted by Microwaves and Conventional Heating Using DBU as Catalyst via Solvent-Free Protocol

Leticia Chavelas-Hernández, Luis G. Hernández-Vázquez, José D. Bahena-Martínez, Alexa B. Arroyo-Colín, Sinuhe G. Flores-Osorio, Gabriel Navarrete-Vázquez, Jaime Escalante

June 24, 2024

In recent years, the use of solvent-free reactions represents a challenge for organic chemists, since it would help to optimize methodologies and contribute to the development of sustainable chemistry. In this regard, our research group has intensified efforts in the search for reactions that can be carried out in the absence of a solvent. In this paper, we present a protocol for the aza-Michael addition of benzylamine to α,β-unsaturated esters to prepare N-benzylated β-amino esters in the presence of catalytic amounts of DBU (0.2 eq) via solvent-free reaction. Depending on the α,β-unsaturated esters, we observed a reduction in reaction times, with good to excellent yields for aza-Michael addition.

Record ID

LAPSE:2024.1323v1

Keywords

aza-Michael addition, DBU, microwaves, solvent free, β-amino esters

Subject

Reaction Engineering

Suggested Citation

Chavelas-Hernández L, Hernández-Vázquez LG, Bahena-Martínez JD, Arroyo-Colín AB, Flores-Osorio SG, Navarrete-Vázquez G, Escalante J. Aza-Michael Additions of Benzylamine to Acrylates Promoted by Microwaves and Conventional Heating Using DBU as Catalyst via Solvent-Free Protocol. (2024). LAPSE:2024.1323v1

Author Affiliations

Chavelas-Hernández L: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico
Hernández-Vázquez LG: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico
Bahena-Martínez JD: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico
Arroyo-Colín AB: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico
Flores-Osorio SG: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico
Navarrete-Vázquez G: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Mexico [ORCID]
Escalante J: Instituto de Investigación en Ciencias Básicas y Aplicadas, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa, Cuernavaca 62210, Mexico [ORCID]

Journal Name

Processes

Volume

12

Issue

1

First Page

34

Year

2023

Publication Date

2023-12-22