LAPSE:2020.1256
Published Article
LAPSE:2020.1256
N-Tosylcarboxamide in C−H Functionalization: More than a Simple Directing Group
December 22, 2020
C−H activation with transition metal catalysis has become an important tool in organic synthesis for the functionalization of low reactive bonds and the preparation of complex molecules. The choice of the directing group (DG) proves to be crucial for the selectivity in this type of reaction, and several different functional groups have been used efficiently. This review describes recent advances in C−H functionalization of aromatic rings directed by a N-tosylcarboxamide group. Results regarding alkenylation, alkoxylation, halogenation, and arylation of C−H in the ortho position to the tosylcarboxamide are presented. Moreover, the advantage of this particular directing group is that it can undergo further transformation and act as CO or CON fragment reservoir to produce, in sequential fashion or one-pot sequence, various interesting (hetero)cycles such as phenanthridinones, dihydroisoquinolinones, fluorenones, or isoindolinones.
Record ID
Keywords
C–H functionalization, Catalysis, directing group, tosylbenzamide
Subject
Suggested Citation
Large B, Terrasson V, Prim D. N-Tosylcarboxamide in C−H Functionalization: More than a Simple Directing Group. (2020). LAPSE:2020.1256
Author Affiliations
Large B: Institut Lavoisier de Versailles, UVSQ, CNRS, Université Paris-Saclay, 78035 Versailles, France [ORCID]
Terrasson V: TIMR (Integrated Transformations of Renewable Matter), ESCOM, Centre de Recherche de Royallieu, Université de Technologie de Compiègne, CS 60319, 60203 Compiègne CEDEX, France [ORCID]
Prim D: Institut Lavoisier de Versailles, UVSQ, CNRS, Université Paris-Saclay, 78035 Versailles, France [ORCID]
Terrasson V: TIMR (Integrated Transformations of Renewable Matter), ESCOM, Centre de Recherche de Royallieu, Université de Technologie de Compiègne, CS 60319, 60203 Compiègne CEDEX, France [ORCID]
Prim D: Institut Lavoisier de Versailles, UVSQ, CNRS, Université Paris-Saclay, 78035 Versailles, France [ORCID]
Journal Name
Processes
Volume
8
Issue
8
Article Number
E981
Year
2020
Publication Date
2020-08-13
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr8080981, Publication Type: Review
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Published Article
LAPSE:2020.1256
This Record
External Link
doi:10.3390/pr8080981
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381
Version History
[v1] (Original Submission)
Dec 22, 2020
Verified by curator on
Dec 22, 2020
This Version Number
v1
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URL Here
https://psecommunity.org/LAPSE:2020.1256
Original Submitter
Calvin Tsay
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