This paper is focused mainly on the production simulation method of a regional integrated energy system under random scenarios for optimal configuration. First, the cooling, heating, and electric load demand of the regional integrated energy system is described quantitatively in the form of time series, as well as the power characteristics of renewable energy, such as wind power and photovoltaic power generation. Then, a typical scenario set of regional integrated energy system configurations considering the random probability characteristics is established through scene clustering. Second, considering the power output characteristics and cost factors of different types of distributed energy, the corresponding technical and economic quantitative model is established. Third, a multi-objective production simulation model of a regional integrated energy system considering configuration constraints and operation constraints is proposed with economic and environmental protection as the main objectives. Finally, the accuracy and effectiveness of the above methods are verified based on a case study of actual engineering.