Due to the dynamic process of maximum power point tracking (MPPT) caused by turbulence and large rotor inertia, variable-speed wind turbines (VSWTs) cannot maintain the optimal tip speed ratio (TSR) from cut-in wind speed up to the rated speed. Therefore, in order to increase the total captured wind energy, the existing aerodynamic design for VSWT blades, which only focuses on performance improvement at a single TSR, needs to be improved to a multi-point design. In this paper, based on a closed-loop system of VSWTs, including turbulent wind, rotor, drive train and MPPT controller, the distribution of operational TSR and its description based on inflow wind energy are investigated. Moreover, a multi-point method considering the MPPT dynamic process for the aerodynamic optimization of VSWT blades is proposed. In the proposed method, the distribution of operational TSR is obtained through a dynamic simulation of the closed-loop system under a specific turbulent wind, and accordingly the multiple design TSRs and the corresponding weighting coefficients in the objective function are determined. Finally, using the blade of a National Renewable Energy Laboratory (NREL) 1.5 MW wind turbine as the baseline, the proposed method is compared with the conventional single-point optimization method using the commercial software Bladed. Simulation results verify the effectiveness of the proposed method.