In this paper, a novel approach to low order harmonic mitigation in fundamental switching frequency modulation is proposed for high power photovoltaic (PV) applications, without trying to solve the cumbersome non-linear transcendental equations. The proposed method allows for mitigation of the first-five harmonics (third, fifth, seventh, ninth, and eleventh harmonics), to reduce the complexity of the required procedure and to allocate few computational resource in the Field Programmable Gate Array (FPGA) based control board. Therefore, the voltage waveform taken into account is different respect traditional voltage waveform. The same concept, known as “voltage cancelation„, used for single-phase cascaded H-bridge inverters, has been applied at a single-phase five-level cascaded H-bridge multilevel inverter (CHBMI). Through a very basic methodology, the polynomial equations that drive the control angles were detected for a single-phase five-level CHBMI. The acquired polynomial equations were implemented in a digital system to real-time operation. The paper presents the preliminary analysis in simulation environment and its experimental validation.