LAPSE:2026.0275
Published Article

LAPSE:2026.0275
Optimization-based Design, Simulation and Data-Driven Learning for Resilient Manufacturing Systems
June 12, 2026
Abstract
Resilience is becoming a top priority across industrial sectors, with increasing pressures to assess it systematically. In this work, we present an optimization-based framework for proactive design and planning under uncertainty of multi-product manufacturing networks, and testing of the reactive strategies available to withstand unforeseen disruptions. Specifically, the design problem is formulated as a two-stage stochastic optimization, integrating multi-period planning and scheduling, aimed towards mitigation against uncertainty. Designs are then fixed and tested through simulated outcomes from out-of-sample uncertainty distributions, with feasibility of operation monitored through the time-to-recover post disruption. Infeasibility triggers a scenario-update procedure via ??-means clustering, whereby critical uncertainty information based on simulated outcomes is integrated in the proactive planning step, including low-probability high-impact scenarios. Modular and non-modular designs are compared to quantify the value of recourse actions with respect to responsiveness to disruptions. Results highlight that adaptable modular designs enable shorter recovery times combined with lower cost commitments. Overall, the framework underpins the development of tools for the anticipation and mitigation of disruptive events and systematic re-design based on continuously updated uncertainty information.
Resilience is becoming a top priority across industrial sectors, with increasing pressures to assess it systematically. In this work, we present an optimization-based framework for proactive design and planning under uncertainty of multi-product manufacturing networks, and testing of the reactive strategies available to withstand unforeseen disruptions. Specifically, the design problem is formulated as a two-stage stochastic optimization, integrating multi-period planning and scheduling, aimed towards mitigation against uncertainty. Designs are then fixed and tested through simulated outcomes from out-of-sample uncertainty distributions, with feasibility of operation monitored through the time-to-recover post disruption. Infeasibility triggers a scenario-update procedure via ??-means clustering, whereby critical uncertainty information based on simulated outcomes is integrated in the proactive planning step, including low-probability high-impact scenarios. Modular and non-modular designs are compared to quantify the value of recourse actions with respect to responsiveness to disruptions. Results highlight that adaptable modular designs enable shorter recovery times combined with lower cost commitments. Overall, the framework underpins the development of tools for the anticipation and mitigation of disruptive events and systematic re-design based on continuously updated uncertainty information.
Record ID
Keywords
Design Under Uncertainty, Multiscale Modelling, Planning & Scheduling, Resilience, Stochastic Optimization, Supply Chain
Subject
Suggested Citation
Sarkis M, Pistikopoulos E. Optimization-based Design, Simulation and Data-Driven Learning for Resilient Manufacturing Systems. Systems and Control Transactions 5:583-591 (2026) https://doi.org/10.69997/sct.106149
Author Affiliations
Sarkis M: Texas A&M University, Energy Institute, College Station, 77843, Texas, United States
Pistikopoulos E: Texas A&M University, Energy Institute, College Station, 77843, Texas, United States. Texas A&M University, Artie McFerrin Department of Chemical Engineering, College Station, 77843, Texas, United States
[Login] to see author email addresses.
Pistikopoulos E: Texas A&M University, Energy Institute, College Station, 77843, Texas, United States. Texas A&M University, Artie McFerrin Department of Chemical Engineering, College Station, 77843, Texas, United States
[Login] to see author email addresses.
Journal Name
Systems and Control Transactions
Volume
5
First Page
583
Last Page
591
Year
2026
Publication Date
2026-06-12
Version Comments
Original Submission
Other Meta
PII: 0583-0591-546-SCT-5-2026, Publication Type: Journal Article
Record Map
Published Article

LAPSE:2026.0275
This Record
External Link

https://doi.org/10.69997/sct.106149
Publisher Version
Data

LAPSE:2026.0044
SI Document - Optimization-based De...
Download
Meta
Record Statistics
Record Views
187
Version History
[v1] (Original Submission)
Jun 12, 2026
Verified by curator on
Jun 12, 2026
This Version Number
v1
Citations
Most Recent
This Version
URL Here
https://psecommunity.org/LAPSE:2026.0275
Record Owner
PSE Press
Links to Related Works
Directly Related to This Work
Publisher Version
Supplementary Material
References Cited
- Chrisandina NJ, Vedant S, Iakovou E, Pistikopoulos EN, El-Halwagi MM. Metrics and methods for resilience-aware design of process systems: advances and challenges. Current Opinion in Chemical Engineering 43:100984 (2024) https://doi.org/10.1016/j.coche.2023.100984
- Marques CM, Moniz S, de Sousa JP, Barbosa-Póvoa AP. A simula-tion-optimization approach to integrate process design and planning decisions under technical and market uncertainties. Comput Chem Eng. 106:796-813.(2017) https://doi:10.1016/j.compchemeng.2017.04.008
- Efthymiadou ME, Charitopoulos VM, Papageorgiou LG. Optimization approach for hydrogen infrastructure planning under uncertainty. Ind. Eng. Chem. Res. 64:7431-7451 (2025) https://doi.org/10.1021/acs.iecr.4c04211
- Guillén?Gosálbez G, Grossmann IE. Optimal design and planning of sustainable chemical supply chains under uncertainty. AIChE Journal 55:99-121 (2008) https://doi.org/10.1002/aic.11662
- Sarkis M, Shah N, Papathanasiou MM. Characterization of key manufacturing uncertainties in next generation therapeutics and vaccines across scales. J Adv Manuf Process. 5: e10158 (2023) https://doi:10.1002/amp2.10158
- Kondili E, Pantelides CC, Sargent RWH. A general algorithm for short-term scheduling of batch operations-i. MILP formulation. Computers & Chemical Engineering 17:211-227 (1993) https://doi.org/10.1016/0098-1354(93)80015-f
(0.1 seconds)
[0.1 s]

