This study evaluates, for the first time, the effects of UV/PMS and UV/H2O2/PMS processes on the degradation of sunscreen agents in synthetic and natural water matrices and compares their effectiveness with the more conventional UV/H2O2. Investigations were conducted using a mixture of organic UV filters containing 4-methylbenzylidene camphor (4-MBC) and 2-ethylhexyl-4-methoxycinnamate. Among the investigated UV-driven AOPs, UV/PMS/H2O2 was the most effective in synthetic water, while in natural water, the highest degradation rate was observed during the degradation of EHMC by UV/PMS. The degradation of UV filters in the UV/PMS system was promoted by sulfate radical (68% of the degradation), with hydroxyl radical contributing approximately 32%, while both radical species contributed approximately equally to the degradation in the UV/H2O2/PMS system. The Vibrio fischeri assay showed an increase in inhibition (up to 70%) at specific stages of UV/H2O2 treatment when applied to natural water, which further decreased to 30%, along with an increase in UV fluence and progressive degradation. The Pseudomonas putida test recorded minor toxicity (<15%) after treatments. Magnetic biochar utilized in conjunction with UV-driven AOPs exhibited superior performance in eliminating residual contaminants, providing an efficient and sustainable approach to mitigate sunscreen agents in water treatment.