Development and Characterization of a Novel Microwave Plasma Source for Enhanced Healing in Wound Treatment

Todor Bogdanov; Maria Simeonova; Lubomir Traikov; Todor Hikov; Andrey Petrov; Dimitar Peychinov; Dimitar Bakalov; Zafer Sabit; Radka Tafradjiiska-Hadjiolova; Rene Mileva

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2024.1857

Published Article

LAPSE:2024.1857

Development and Characterization of a Novel Microwave Plasma Source for Enhanced Healing in Wound Treatment

Todor Bogdanov, Maria Simeonova, Lubomir Traikov, Todor Hikov, Andrey Petrov, Dimitar Peychinov, Dimitar Bakalov, Zafer Sabit, Radka Tafradjiiska-Hadjiolova, Rene Mileva

August 23, 2024

Our study explores the potential of a novel microwave plasma source for enhancing wound healing in BALB-C mouse models. Chronic wounds, particularly in diabetic individuals, present significant challenges due to impaired regenerative capacity. Cold Atmospheric Plasma (CAP) has emerged as a promising approach, offering diverse therapeutic benefits. However, its specific efficacy in the context of diabetic wounds remains underexplored. We developed and characterized a microwave plasma source optimized for wound treatment, inducing acute wounds and treating them with CAP in a controlled experimental setup. The treated group exhibited accelerated wound closure compared to controls, suggesting CAP’s potential to enhance the healing process. Our findings underscore CAP’s multifaceted impact on the wound healing cascade, highlighting its ability to promote angiogenesis, modulate inflammatory responses, and exhibit antimicrobial properties. These results position CAP as a promising intervention in acute wound management, paving the way for further exploration of its therapeutic potential in clinical settings.

Record ID

LAPSE:2024.1857

Keywords

argon plasma, cold atmospheric plasma, microwave plasma, microwave plasma, plasma device, tissue regeneration, wound care, wound healing, wound regeneration

Subject

Biosystems

Suggested Citation

Bogdanov T, Simeonova M, Traikov L, Hikov T, Petrov A, Peychinov D, Bakalov D, Sabit Z, Tafradjiiska-Hadjiolova R, Mileva R. Development and Characterization of a Novel Microwave Plasma Source for Enhanced Healing in Wound Treatment. (2024). LAPSE:2024.1857

Author Affiliations

Bogdanov T: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria [ORCID]
Simeonova M: Faculty of Physics, Sofia University “St. Kliment Ohridski”, “James Boucher” bul. No. 5., 1164 Sofia, Bulgaria
Traikov L: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria [ORCID]
Hikov T: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria [ORCID]
Petrov A: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria [ORCID]
Peychinov D: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria
Bakalov D: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria [ORCID]
Sabit Z: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria
Tafradjiiska-Hadjiolova R: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria
Mileva R: Faculty of Medicine, Medical University of Sofia “St. Georgi Sofiyski”, St. No. 1, 1431 Sofia, Bulgaria

Journal Name

Processes

Volume

12

Issue

7

First Page

1501

Year

2024

Publication Date

2024-07-17