The overarching goal of process design (Figure 1) is to find technologically feasible, operable, economically attractive, safe and sustainable processing pathways and process configurations with specifications for the connectivity and design of unit operations that perform a set of tasks using selected functional materials (e.g., catalysts, solvents, sorbents, etc.) to convert a set of feed-stocks or raw materials into a set of products with desired quality at a scale that satisfies the demand. Process synthesis and integration can further screen, optimize and improve these pathways for given techno-econo-environmental targets or objectives. These objectives may include, but are not limited to, minimizing the overall investment and processing costs, minimizing the energy consumption, minimizing the emissions or wastes, maxim-zing the profit, and enhancing the safety, operability, controllability, flexibility, circularity, and sustainability, among others... (ABSTRACT ABBREVIATED)