A new idea to deal with the backmixing problem in a scaled-up multi-inlet vortex mixer is proposed in this paper. Firstly, a Reynolds-averaged Navier−Stokes−large-eddy simulation hybrid model was used to simulate the flow field in a vortex mixer, and the numerical simulation results were compared with those from a particle image velocimetry experiment in order to validate the shielded detached eddy simulation model in the rotating shear flow. Then, by adding a series of columns in the mixing chamber, the formation of wake vortexes was promoted. The flow field in the vortex mixer with different column arrangements were simulated, and the residence time distribution curves of the fluid were obtained. Meanwhile, the degree of backmixing in the vortex mixer was evaluated by means of a tanks-in-series model. In the total ten cases related with four groups of variables, it was found that increasing the diameter of the column was the most efficient for weakening the backmixing in the vortex mixer. Specifically, the vortexes made the kinetic energy of the fluid more evenly distributed in the center of the mixing chamber, thereby eliminating the low-pressure area. After structural adjustment, the number of equivalent mixers was increased by 55%, and the peak number of residence time distribution curves was reduced from four to one.