LAPSE:2023.5246
Published Article
LAPSE:2023.5246
Health Benefits and Pharmacological Properties of Hinokitiol
February 23, 2023
Abstract
Hinokitiol is a natural bioactive compound found in several aromatic and medicinal plants. It is a terpenoid synthetized and secreted by different species as secondary metabolites. This volatile compound was tested and explored for its different biological properties. In this review, we report the pharmacological properties of hinokitiol by focusing mainly on its anticancer mechanisms. Indeed, it can block cell transformation at different levels by its action on the cell cycle, apoptosis, autophagy via inhibiting gene expression and dysregulating cellular signaling pathways. Moreover, hinokitiol also exhibits other pharmacological properties, including antidiabetic, anti-inflammatory, and antimicrobial effects. It showed multiple and several effects through its inhibition, interaction and/or activation of the main cellular targets inducing these pathologies.
Hinokitiol is a natural bioactive compound found in several aromatic and medicinal plants. It is a terpenoid synthetized and secreted by different species as secondary metabolites. This volatile compound was tested and explored for its different biological properties. In this review, we report the pharmacological properties of hinokitiol by focusing mainly on its anticancer mechanisms. Indeed, it can block cell transformation at different levels by its action on the cell cycle, apoptosis, autophagy via inhibiting gene expression and dysregulating cellular signaling pathways. Moreover, hinokitiol also exhibits other pharmacological properties, including antidiabetic, anti-inflammatory, and antimicrobial effects. It showed multiple and several effects through its inhibition, interaction and/or activation of the main cellular targets inducing these pathologies.
Record ID
Keywords
cancer, hinokitiol, NF-κB, pharmacological action, signaling pathways
Subject
Suggested Citation
El Hachlafi N, Lakhdar F, Khouchlaa A, Bakrim S, El Omari N, Balahbib A, Shariati MA, Zengin G, Fikri-Benbrahim K, Orlando G, Ferrante C, Meninghi L, Bouyahya A. Health Benefits and Pharmacological Properties of Hinokitiol. (2023). LAPSE:2023.5246
Author Affiliations
El Hachlafi N: Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohmed Ben Abdellah University, Fez B.P. 2626, Morocco [ORCID]
Lakhdar F: Laboratory of Marine Biotechnology and Environment, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco [ORCID]
Khouchlaa A: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat B.P. 1014, Morocco
Bakrim S: Molecular Engineering, Valorization and Environment Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir B.P. 32/S, Morocco
El Omari N: Laboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat B.P. 9154, Morocco
Balahbib A: Laboratory of Biodiversity, Ecology and Genome, Faculty of Sciences, Mohammed V University, Rabat B.P. 1014, Morocco [ORCID]
Shariati MA: Departement of Technology of Food Production, K.G. Razumoysky Moscow State University of Technologies and Management, 109004 Moscow, Russia [ORCID]
Zengin G: Biochemistry and Physiology Research Laboratory, Department of Biology, Faculty of Science, Selcuk University, 42130 Konya, Turkey [ORCID]
Fikri-Benbrahim K: Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohmed Ben Abdellah University, Fez B.P. 2626, Morocco
Orlando G: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy
Ferrante C: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy [ORCID]
Meninghi L: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy [ORCID]
Bouyahya A: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat B.P. 1014, Morocco [ORCID]
Lakhdar F: Laboratory of Marine Biotechnology and Environment, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco [ORCID]
Khouchlaa A: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat B.P. 1014, Morocco
Bakrim S: Molecular Engineering, Valorization and Environment Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir B.P. 32/S, Morocco
El Omari N: Laboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat B.P. 9154, Morocco
Balahbib A: Laboratory of Biodiversity, Ecology and Genome, Faculty of Sciences, Mohammed V University, Rabat B.P. 1014, Morocco [ORCID]
Shariati MA: Departement of Technology of Food Production, K.G. Razumoysky Moscow State University of Technologies and Management, 109004 Moscow, Russia [ORCID]
Zengin G: Biochemistry and Physiology Research Laboratory, Department of Biology, Faculty of Science, Selcuk University, 42130 Konya, Turkey [ORCID]
Fikri-Benbrahim K: Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohmed Ben Abdellah University, Fez B.P. 2626, Morocco
Orlando G: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy
Ferrante C: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy [ORCID]
Meninghi L: Department of Pharmacy, Botanic Garden “Giardino dei Semplici”, Università Degli Studi “Gabriele d’Annunzio”, Via dei Vestini 31, 66100 Chieti, Italy [ORCID]
Bouyahya A: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University, Rabat B.P. 1014, Morocco [ORCID]
Journal Name
Processes
Volume
9
Issue
9
First Page
1680
Year
2021
Publication Date
2021-09-18
ISSN
2227-9717
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Original Submission
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PII: pr9091680, Publication Type: Review
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LAPSE:2023.5246
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https://doi.org/10.3390/pr9091680
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Feb 23, 2023
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