Due to today’s technological development and information progress, an increasing number of physical systems have become interconnected and linked together through communication networks, thus resulting in Cyber-Physical Systems (CPSs). Continuous manufacturing, which involves the manufacture of products without interruption, has become increasingly important in many industries, including the pharmaceutical and chemical industries. CPSs can be used to control and monitor the production process, which is essential in enabling continuous manufacturing. This paper is focused on the modeling and control of physical systems required in tablet production using dry granulation. Tablets are a type of oral dosage form that is commonly used in the pharmaceutical industry. They are solid, compressed forms of medication that are formulated to release the active ingredients in a manner that allows for optimal absorption and efficacy. Thus, a model predictive control (MPC) strategy is applied to a plant model to test the designed controller and to analyze the obtained performances. The simulation results are compared with those obtained using other control algorithms, linear quadratic regulator (LQR) and proportional-integral-derivative (PID), applied to the same plant model. The results showed that the predictive control strategy performed significantly better than the other two control strategies.