Development and Experimental Evaluation of Some Silver Nanoparticles with Antimicrobial Potential

Bruno Ștefan Velescu; Marina Ionela Ilie; Anca Ioana Amzăr; Raluca Elisabeta Lupașcu; Ilinca Mihaela Marandiuc; Miruna-Maria Apetroaei; Andreea Letiția Arsene; Emilian Ionuț Blejan; Octvian Alexandru Nedea; Toma Fistos; Radu Claudiu Fierăscu; Florica Bărbuceanu; Cristina Țoca; Irina Fierăscu; Denisa Ioana Udeanu; Manuela Ghica; Doina Drăgănescu; Pavel Călin Cobelschi

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2023.35284

Published Article

LAPSE:2023.35284

Development and Experimental Evaluation of Some Silver Nanoparticles with Antimicrobial Potential

Bruno Ștefan Velescu, Marina Ionela Ilie, Anca Ioana Amzăr, Raluca Elisabeta Lupașcu, Ilinca Mihaela Marandiuc, Miruna-Maria Apetroaei, Andreea Letiția Arsene, Emilian Ionuț Blejan, Octvian Alexandru Nedea, Toma Fistos, Radu Claudiu Fierăscu, Florica Bărbuceanu, Cristina Țoca, Irina Fierăscu, Denisa Ioana Udeanu, Manuela Ghica, Doina Drăgănescu, Pavel Călin Cobelschi

April 28, 2023

By adjusting the synthesis process, silver nanoparticles (AgNp) of various shapes, sizes, and structures can be obtained, all of which have a substantial impact on the biological effect, notably, the regulation of antibacterial activity in the present circumstances of growing bacterial resistance. Due to their relatively small size, nanoparticles may be disseminated evenly throughout the body of the experimental animal, even at low doses, and exert more potent antibacterial activities. Our research was centered on the synthesis, production, and biological evaluation of antibacterial silver nanoparticles. Using the Turkevich method, we were able to effectively synthesize and characterize nanoscale silver particles, with an average crystallite size of 9.49 nm. We examined their acute toxicity and pharmacokinetic characteristics in rats after administering a single dosage. In addition, we evaluated the biological effect of topical AgNp suspension on the progression of burn-type lesions in the experimental animals. The pharmacokinetic profile demonstrated that the plasma concentration of silver nanoparticles, as well as their clearance rate, and dispersion throughout the body, are significantly enhanced in large rodent species. The restorative effect of synthesized silver nanoparticles in the form of a suspension in distilled water was corroborated by the values of the hematological parameters. These results demonstrated an intense stimulation of the cellular and molecular processes of the local immune defense, which has resulted in significantly faster regeneration in the AgNp-treated group.

Record ID

LAPSE:2023.35284

Keywords

AgNp, antimicrobial potential, pharmacokinetics, silver nanoparticles, topical treatment, Turkevich method

Subject

Materials

Suggested Citation

Velescu BȘ, Ilie MI, Amzăr AI, Lupașcu RE, Marandiuc IM, Apetroaei MM, Arsene AL, Blejan EI, Nedea OA, Fistos T, Fierăscu RC, Bărbuceanu F, Țoca C, Fierăscu I, Udeanu DI, Ghica M, Drăgănescu D, Cobelschi PC. Development and Experimental Evaluation of Some Silver Nanoparticles with Antimicrobial Potential. (2023). LAPSE:2023.35284

Author Affiliations

Velescu BȘ: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Ilie MI: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Amzăr AI: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Lupașcu RE: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Marandiuc IM: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Apetroaei MM: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Arsene AL: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Blejan EI: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Nedea OA: Faculty of Biotechnical Systems Engineering, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
Fistos T: National Institute for Research and Development in Chemistry and Petrochemistry, 060021 Bucharest, Romania
Fierăscu RC: National Institute for Research and Development in Chemistry and Petrochemistry, 060021 Bucharest, Romania
Bărbuceanu F: National Institute for Diagnosis and Animal Health, 050557 Bucharest, Romania [ORCID]
Țoca C: National Institute for Diagnosis and Animal Health, 050557 Bucharest, Romania
Fierăscu I: National Institute for Research and Development in Chemistry and Petrochemistry, 060021 Bucharest, Romania [ORCID]
Udeanu DI: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Ghica M: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Drăgănescu D: Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Cobelschi PC: Faculty of Medicine, Transilvania University, 500019 Brașov, Romania

Journal Name

Processes

Volume

11

Issue

4

First Page

1212

Year

2023

Publication Date

2023-04-14