A competent methodology based on the active power loss reduction for optimal placement and sizing of distributed generators (DGs) in an active distribution network (ADN) with several soft open points (SOPs) is proposed. A series of SOP combinations are explored to generate different network structures and they are utilized in the optimization framework to identify the possible solutions with minimum power loss under normal network conditions. Furthermore, a generalized methodology to optimize the size and the location of a predefined number of DGs with a predefined number of SOPs is presented. A case study on the modified IEEE 33 bus system with three DGs and five SOPs was conducted and hence the overall network power loss and the voltage improvement were examined. The findings reveal that the system loss of the passive network without SOPs and DGs is reduced by 79.5% using three DGs and five SOPs. In addition, this research work introduces a framework using the DG size and the impedance to the DG integration node, to propose a region where the DGs can be optimally integrated into an ADN that includes several SOPs.