With the development trend of large-scale and flexible structures in engineering, the research on drag reduction of structures becomes more urgent. This paper presents a drag reduction design method for box girders based on the bionic method. Through the analysis of the Ostracion cubicus body shape, three features of the “fish mouth”, which were helpful for drag reduction were extracted. Then the bionic design model with the height of the box girder (D) as the design variable was obtained. By attaching lightweight materials to the windward side, the bionic shape of the structure can be realized without changing the loading characteristics of the original structure. Taking a box girder (rectangular cylinder, side ratio B/D = 0.6) as a prototype, the flow around two structures (rectangular cylinder and bionic attachment cylinder) was numerically simulated. The results show that the drag coefficient of the bionic attachment structure is reduced by 66.5%. The reduction of wind-load means that this method can save energy consumption of the equipment. Meanwhile, the aerodynamic parameter oscillation of the structure is weakened, which represents that the bionic attachment structure can effectively reduce the wind-induced vibration on the structure and improve the stability of the structure in the wind field.