This contribution is focused on the fuel economy improvement of the Miller cycle under part-load characteristics on a supercharged DI (Direct Injection) gasoline engine. Firstly, based on the engine bench test, the effects with the Miller cycle application under 3000 rpm were studied. The results show that the Miller cycle has different extents of improvement on pumping loss, combustion and friction loss. For low, medium and high loads, the brake thermal efficiency of the baseline engine is increased by 2.8%, 2.5% and 2.6%, respectively. Besides, the baseline variable valve timing (VVT) is optimized by the test. Subsequently, the 1D CFD (Computational Fluid Dynamics) model of the Miller cycle engine after the test optimization at the working condition of 3000 rpm and BMEP (Brake Mean Effective Pressure) = 10 bar was established, and the influence of the combined change of intake and exhaust valve timing on Miller cycle was studied by simulation. The results show that as the effect of the Miller cycle deepens, the engine’s knocking tendency decreases, so the ignition timing can be further advanced, and the economy of the engine can be improved. Compared with the brake thermal efficiency of the baseline engine, the final result after simulation optimization is increased from 34.6% to 35.6%, which is an improvement of 2.9%.