Improvements in internal combustion engine efficiency can be achieved with proper thermal management. In this work, a simulation tool for the preliminary analysis of the engine cooling control is developed and a model-based controller, which enforces the coolant flow rate by means of an electrically driven pump is presented. The controller optimizes the coolant flow rate under each engine operating condition to guarantee that the engine temperatures and the coolant boiling levels are kept inside prescribed constraints, which guarantees efficient and safe engine operation. The methodology is validated at the experimental test rig. Several control strategies are analyzed during a standard homologation cycle and a comparison of the proposed methodology and the adoption of the standard belt-driven pump is provided. The results show that, according to the control strategy requirements, a fuel consumption reduction of up to about 8% with respect to the traditional cooling system can be achieved over a whole driving cycle. This proves that the proposed methodology is a useful tool for appropriately cooling the engine under the whole range of possible operating conditions.