Considering the pressing challenges of supply security and climate change, advanced processes to produce electricity and biofuels from biomass have to be developed. Biomass gasification is a very promising technology, but there is a lack of comprehensive reviews, specifically on the technologies for hydrogen chloride hot gas cleanup, which are necessary in order to work at the same temperature and respect the limits of advanced downstream components. In this review, the Cl content of the main biomasses in Europe is given, and data on syngas content and the tolerance of downstream equipment are highlighted. Hot gas cleaning technologies, which have the advantage of improved thermal efficiency are reviewed, analyzing the thermodynamic and primary and secondary methods. This review identifies NaAlO2 and Na2CO3 within 450−550 °C as the most effective sorbents, which are able to reduce the concentration of HCl below 1 ppm. Nevertheless, H2S cannot be simultaneously removed and has to be removed first, because it reduces the HCl adsorption sorbent capacity.