This study uses an artificial neural network (ANN) as an intelligent controller for the management and scheduling of a number of microgrids (MGs) in virtual power plants (VPP). Two ANN-based scheduling control approaches are presented: the ANN-based backtracking search algorithm (ANN-BBSA) and ANN-based binary practical swarm optimization (ANN-BPSO) algorithm. Both algorithms provide the optimal schedule for every distribution generation (DG) to limit fuel consumption, reduce CO2 emission, and increase the system efficiency towards smart and economic VPP operation as well as grid decarbonization. Different test scenarios are executed to evaluate the controllers’ robustness and performance under changing system conditions. The test cases are different load curves to evaluate the ANN’s performance on untrained data. The untrained and trained load models used are real-load parameter data recorders in northern parts of Malaysia. The test results are analyzed to investigate the performance of these controllers under varying power system conditions. Additionally, a comparative study is performed to compare their performances with other solutions available in the literature based on several parameters. Results show the superiority of the ANN-based controllers in terms of cost reduction and efficiency.