In practice, R&D in public organizations in developing countries is confronted with a variety of failures related to supporting management disciplines. The primary goal of this study is to address this issue through multiple-criteria decision making, which includes the DANP (DEMATEL-based ANP) approach. The DANP approach helps to resolve the classification issue that arises as a result of interdependence and feedback characteristics among the capabilities related to supporting management disciplines, allowing weak capabilities to be prioritized based on their interdependence. In the case of criteria weighting, the empirical result in terms of the degree of the net causal relationship had a greater influence on other criteria; however, in terms of dimensions, the technology management process capability had a greater significance on other dimensions, while the innovation management process capability had the least significance on other dimensions. The studies were based on relevant capabilities under a generic perspective so as to oppose country-specific reviews. However, for empirical testing, the proposed framework needs to fit into a country-specific context. According to specific conditions, Pakistan is considered as a case of empirical testing, providing the experts from the multidisciplinary field of science and technology with robust professional credentials in managing multi-mission R&D from public organizations.