LAPSE:2022.0123v1
Published Article
LAPSE:2022.0123v1
Extracellular Vesicle Transportation and Uptake by Recipient Cells: A Critical Process to Regulate Human Diseases
Zhi Hao Kwok, Chenghao Wang, Yang Jin
October 31, 2022
Emerging evidence highlights the relevance of extracellular vesicles (EVs) in modulating human diseases including but not limited to cancer, inflammation, and neurological disorders. EVs can be found in almost all types of human body fluids, suggesting that their trafficking may allow for their targeting to remote recipient cells. While molecular processes underlying EV biogenesis and secretion are increasingly elucidated, mechanisms governing EV transportation, target finding and binding, as well as uptake into recipient cells remain to be characterized. Understanding the specificity of EV transport and uptake is critical to facilitating the development of EVs as valuable diagnostics and therapeutics. In this mini review, we focus on EV uptake mechanisms and specificities, as well as their implications in human diseases.
Keywords
endocytosis, extracellular vesicles, uptake specificity
Subject
Suggested Citation
Kwok ZH, Wang C, Jin Y. Extracellular Vesicle Transportation and Uptake by Recipient Cells: A Critical Process to Regulate Human Diseases. (2022). LAPSE:2022.0123v1
Author Affiliations
Kwok ZH: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, MA 02118, USA
Wang C: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, MA 02118, USA
Jin Y: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University Medical Campus, Boston, MA 02118, USA
Journal Name
Processes
Volume
9
Issue
2
First Page
273
Year
2021
Publication Date
2021-01-31
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9020273, Publication Type: Review
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LAPSE:2022.0123v1
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doi:10.3390/pr9020273
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Oct 31, 2022
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License
CC BY 4.0
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Version History
[v1] (Original Submission)
Oct 31, 2022
 
Verified by curator on
Oct 31, 2022
This Version Number
v1
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https://psecommunity.org/LAPSE:2022.0123v1
 
Original Submitter
Mina Naeini
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